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2 edition of Genetic toxicity of aryl amines in the intestine tract found in the catalog.

Genetic toxicity of aryl amines in the intestine tract

Adrian John Percy

Genetic toxicity of aryl amines in the intestine tract

by Adrian John Percy

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Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D) - University of Birmingham, School of Biochemistry, 1992.

Statementby Adrian John Percy.
ID Numbers
Open LibraryOL20860453M

Abstract. In the context of food toxicology the gastrointestinal tract is of major importance in that it is the primary site of exposure to potential toxicants and the concentrations involved are likely to be higher than those in other :// BNF also causes significant toxicity on the development of zebrafish embryos, and is considered a model PAH as it induces the expression of aryl hydrocarbon receptor (AHR), which medi- ates the

The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins   Intestinal cytochrome P subclass 1A1 (CYP1A1) contributes to a metabolic “shield” protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR) and the AHR nuclear ?id=/

The human gut microbiota is a dynamic ecosystem formed by a pool of – adherent and non-adherent bacterial species belonging mostly to two dominant phyla, the Firmicutes and the ?_name=subjects_archaea.   Genetic variation in other cytochrome Ps can also be important modulators of cancer risk. CYP1A2 metabolizes arylamines, heterocyclic amines and aflatoxins. In human liver there is a greater than 40 fold variation in expression of the CYP1A2 gene. CYP2E1 metabolizes N-nitrosamines, butadiene, benzene and carbon tetrachloride. The activity


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Genetic toxicity of aryl amines in the intestine tract by Adrian John Percy Download PDF EPUB FB2

The toxicity of histamine is enhanced by the presence of other biogenic amines (putrescine and cadaverine) in foods, inhibiting histamine-metabolizing enzymes in the intestine.

49 DAO is the major histamine catabolizing enzyme in the intestinal ://?isbn=   Aryl- amines are directly used in inks for pens, in shoe cream, and in dyes for ink pads. 4-Methoxy-m-phenylenediamine and o- or p-phenylenediamines are used in hair dyes.

The bicyclic diamino compounds, such as benzidine, 3,3'-dimethylbenzidine, 3,3'-di-methoxybenzidine, and 3,3'-dichlorobenzidine, have been used for the production of azo :// Aromatic Amine.

Aromatic amines could contribute to uremic encephalopathy by serving as false neurotransmitters, Infusion of phenol or p-cresol into dogs results in a variety of neurologic symptoms, and conjugated phenols can inhibit ATPases and ion transport systems, leading to changes in intracellular ionic composition and abnormal cellular :// Biogenic amines have been shown to occur in various foods like fish, meat, cheese, vegetables, and wines.

43–47 TAAR agonists, such as 2-PEA, TYR, and 3-iodothyronamine (T1AM), have been identified in the plasma of healthy individuals at concentrations of 14–66 nM.

4–6 Biogenic amines may thus enter the bloodstream postprandially, and Most of the studies using rodents as animal models to investigate the gastrointestinal tract cancers of GI tract have placed emphasis on the number of tumors present in the small intestine as primary endpoint and tumor incidences in colon have been overlooked as evident from the following studies.

Oral administration of B(a)P through gavage and The presence of this enzyme at high levels in the small intestine has implications for the oral bioavailability of a number of drugs, including salbutamol (Morgan et al., ), as well as many dietary compounds (such as biogenic amines), which are substrates (Eisenhofer et al., ).

Introduction. The human gut microbiota is a dynamic ecosystem formed by a pool of – adherent and non-adherent bacterial species belonging mostly to two dominant phyla, the Firmicutes and the Bacteroidetes. 1 Although the composition of an adult microbiota remains relatively stable, it is well known that the microbial diversity is acquired very early in life within the first hours   Cytochromes present a genetic polymorphism intra- or interindividual and intra- or interethnic.

Changes in the pharmacokinetic profile of the drug are associated with increased toxicity due to reduced metabolism, altered efficacy of the drug, increased production of   Animals.

C57BL/6 WT mice and BTLR2 tm1Kir /J mice were obtained from the Jackson Laboratory, Bar Harbor, Maine, USA. BTLR2 tm1Kir /J mice are homozygous for the TLR2 tm1Kir mutation and do not produce functional TLR2 were 13–14 weeks at the start of the experiment.

Animals were kept under 12 h-light-dark cycles at 22°://   The UPR has recently drawn great interest after it was linked to Crohn’s disease (Kaser and Blumberg, ).In mice, genetic absence of XBP1 in epithelial cells results in spontaneous ileitis and increased DSS colitis severity (Kaser et al., ).The latter was abrogated by antibiotics, suggesting that the mechanism of disease involved an abnormal response to the microbiota or a shift to a   The aromatic component amines of azo dyes may be absorbed into the body through the lungs, the gastrointestinal tract or the skin (ECDIN, ).

Mutagenicity In general, the correlation between results of mutagenicity tests and carcinogenicity   Protein is essential to growth and metabolism. Many factors influence dietary protein digestion and utilization in the gastrointestinal tract. Probiotics have attracted increasing attention in recent years owing to their broad health benefits, which may include a positive influence on the digestion and utilization of ://   N-Hydroxylation has been shown to play a key role in the toxicity of arylamines [].

However a number of inactivating pathways compete with N- hydroxylation []. N-Glucuronidation of the aryl- amines may be a major factor determining their metabolic fate and their disposition [5, ].

The aryl hydrocarbon receptor (AhR) is a ligand-activated receptor that mediates toxicity of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; Denison and Nagy ).

@article{osti_, title = {Review: putative mutagens and carcinogens in foods. VII. Genetic toxicology of the diet}, author = {Hatch, F T and MacGregor, J T and Zeiger, E}, abstractNote = {Individual reviews of approximately 30 papers presented at the Fourth International Conference on Environmental Mutagens are presented in this :// CYP1A1, referred to historically as aryl hydrocarbon hydroxylase, is expressed predominantly in extrahepatic tissues and has been reported to be the most prominent inducible form in rat small intestine.

13, 85, Although, in contrast to most CYP genes amongst the families 1–3, the CYP1A1 gene is relatively well conserved, Xenobiotic metabolism involves the biochemical modification of drugs and phytochemicals in living organisms, including humans and other animals.

In the intestine, the gut microbiota catalyzes the conversion of hydrophilic drugs into absorbable, hydrophobic compounds through hydroxyzation and reduction. Drugs and phytochemicals are transformed into bioactive (sulfasalazine, lovastatin, and   Growing evidence indicates that the human gut microbiota interacts with xenobiotics, including persistent organic pollutants and foodborne chemicals.

The toxicological relevance of the gut Ackerman, D. M., and K. Leibman. Effect of experimental diabetes on drug metabolism in the Metab. Dispos. – Google Scholar A review on biogenic amines in food and feed: Toxicological aspects, impact on health and control measures Article (PDF Available) in Animal Production Science January with Reads.

In the genetic absence of the Cyp1a1 gene, other oxidative enzymes — CYP1B1, CYP2C and prostaglandin H synthase — are responsible for BaP–DNA adduct formation and BaP-mediated toxicity Four aromatic amines are known to lead to urinary tract cancer in exposed humans, and some are also responsible for the induction of methemoglobinemia.mutagenicity, and genetic toxicity of p—cresidine.

Furthermore, studies on the potential for teratogenicity and reproductive toxicity need to be performed. Chew. — ?Dockey=(). Regulation of cytochrome PA1 expression in rat small intestine.

(). Role of hydroxyeicosatetraenoic acid (HETE) in vascular system. (). Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.

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